Could you elaborate on what you are trying to do, generally speaking, when you plug in a Zip drive such as a firewire or USB one? All you need is a driver to allow the computer to interface with the drive. If you can provide your make and mode I can further assist.
I have a ZIP 100, P/N DDXZ100P2 and originally connected to a computer parallel (printer) port. I have a parallel to USB adapter to connect it to my Lenovo T540p laptop running windows 11 Pro. I have the install disk, a 3 1/2 inch floppy disk dated NOV 1996 for DOS/WIN95 5.20. I tried using a 3 1/2 inch disk drive connected by USB to load the program but the disk drive was not recognized.
I connected the disk drive to a Toshiba Satellite running WIN XP and could use the 3 1/2 inch disk drive but it could not load the ZIP 100 install disk.