Sure there is a difference, however, why don’t you let us know what you are trying to configure or accomplish so we can better assist.

I see you were asking the same question over a year ago, what fun project are you working on?

If you are not using the cable for POE you can expect the cables to be interchangable.

Conductor Size/Resistance
Heat generation can be the result of conductor resistance in PoE applications. To improve conductor resistance, choose a cable with a larger conductor size. A CAT6A cable has a larger conductor size than CAT5e cable, providing less resistance. The greater the conductor size of the cable, the more it can reduce conductor resistance.