Sure there is a difference, however, why don’t you let us know what you are trying to configure or accomplish so we can better assist.
I see you were asking the same question over a year ago, what fun project are you working on?
If you are not using the cable for POE you can expect the cables to be interchangable.
Heat generation can be the result of conductor resistance in PoE applications. To improve conductor resistance, choose a cable with a larger conductor size. A CAT6A cable has a larger conductor size than CAT5e cable, providing less resistance. The greater the conductor size of the cable, the more it can reduce conductor resistance.